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PUBLICATIONS

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Demystifying oral epithelial dysplasia: a histological guide.

Hankinson P, Mahmood H, Walsh H, Speight PM, Khurram SA.

Pathology. 2023 Nov 16:S0031-3025(23)00287-8.

doi: 10.1016/j.pathol.2023.10.002.

PMID: 38030478

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Prognostic importance of mitosis quantification and PHH3 expression in oral epithelial dysplasia.

Sathyamoorthy H, Mahmood H, Zubir AZA, Hankinson PKhurram SA.

Virchows Arch. 2023 Oct 26.

doi: 10.1007/s00428-023-03668-6.

PMID: 37882821

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LYSTO: The Lymphocyte Assessment Hackathon and Benchmark Dataset.

Jiao Y, van der Laak J, Albarqouni S, Li Z, Tan T, Bhalerao A, Cheng S, Ma J, Pocock J, Pluim JPW, Koohbanani NA, Bashir RMS, Raza SEA, Liu S, Graham S, Wetstein S, Khurram SA, Liu X, Rajpoot N, Veta M, Ciompi F.

IEEE J Biomed Health Inform. 2023 Oct 25;PP.

doi: 10.1109/JBHI.2023.3327489. 

PMID: 37878422

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Development and validation of a multivariable model for prediction of malignant transformation and recurrence of oral epithelial dysplasia.

Mahmood H, Shephard A, Hankinson P, Bradburn M, Araujo ALD, Santos-Silva AR, Lopes MA, Vargas PA, McCombe KD, Craig SG, James J, Brooks J, Nankivell P, Mehanna H, Rajpoot N, Khurram SA.

Br J Cancer. 2023 Sep 27.

doi: 10.1038/s41416-023-02438-0.

PMID: 37758836

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The use of deep learning state-of-the-art architectures for oral epithelial dysplasia grading: A comparative appraisal.

Araújo ALD, Silva VMD, Moraes MC, de Amorim HA, Fonseca FP, Sant'Ana MSP, Mesquita RA, Mariz BALA, Pontes HAR, de Souza LL, Saldivia-Siracusa C, Khurram SA, Pearson AT, Martins MD, Lopes MA, Vargas PA, Kowalski LP, Santos-Silva AR.

J Oral Pathol Med. 2023 Sep 15.

doi: 10.1111/jop.13477.

PMID: 37712321

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A Novel Deep Learning Algorithm for Human Papillomavirus Infection Prediction in Head and Neck Cancers Using Routine Histology Images.

Wang R, Khurram SA, Walsh H, Young LS, Rajpoot N.

Mod Pathol. 2023 Aug 29;36(12):100320.

doi: 10.1016/j.modpat.2023.100320.

PMID: 37652399

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A digital score of peri-epithelial lymphocytic activity predicts malignant transformation in oral epithelial dysplasia.

Bashir RMS, Shephard AJ, Mahmood H, Azarmehr N, Raza SEA, Khurram SA, Rajpoot NM.

J Pathol. 2023 Aug;260(4):431-442.

doi: 10.1002/path.6094.

PMID: 37294162

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Machine learning for the prediction of toxicities from head and neck cancer treatment: A systematic review with meta-analysis.

Araújo ALD, Moraes MC, Pérez-de-Oliveira ME, Silva VMD, Saldivia-Siracusa C, Pedroso CM, Lopes MA, Vargas PA, Kochanny S, Pearson A, Khurram SA, Kowalski LP, Migliorati CA, Santos-Silva AR.

Oral Oncol. 2023 Apr 4;140:106386.

doi: 10.1016/j.oraloncology.2023.106386.

PMID: 37023561 

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Epithelial salivary gland tumors in pediatric patients: An international collaborative study.

Quixabeira Oliveira GA, Pérez-DE-Oliveira ME, Robinson L, Khurram SA, Hunter K, Speight PM, Kowalski LP, Lopes Pinto CA, Sales De Sá R, Mendonça EF, Sousa-Neto SS, de Carlucci Junior D, Mariano FV, Altemani AMAM, Martins MD, Zanella VG, Perez DEDC, Dos Santos JN, Romañach MJ, Abrahão AC, Andrade BAB, Pontes HAR, Jorge Junior J, Santos-Silva AR, Lopes MA, Van Heerden WFP, Vargas PA.

Int J Pediatr Otorhinolaryngol. 2023 Mar 21;168:111519.

doi: 10.1016/j.ijporl.2023.111519.

PMID: 36965251

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Machine learning for detection and classification of oral potentially malignant disorders: A conceptual review.

de Souza LL, Fonseca FP, Araújo ALD, Lopes MA, Vargas PA, Khurram SA, Kowalski LP, Dos Santos HT, Warnakulasuriya S, Dolezal J, Pearson AT, Santos-Silva AR.

J Oral Pathol Med. 2023 Mar;52(3):197-205.

doi: 10.1111/jop.13414. Epub 2023 Mar 8.

PMID: 36792771

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Machine learning concepts applied to oral pathology and oral medicine: A convolutional neural networks' approach.

Araújo ALD, da Silva VM, Kudo MS, de Souza ESC, Saldivia-Siracusa C, Giraldo-Roldán D, Lopes MA, Vargas PA, Khurram SA, Pearson AT, Kowalski LP, de Carvalho ACPLF, Santos-Silva AR, Moraes MC.

J Oral Pathol Med. 2023 Feb;52(2):109-118.

doi: 10.1111/jop.13397. Epub 2023 Jan 4.

PMID: 36599081

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Clinical predictors of malignant transformation and recurrence in oral potentially malignant disorders: A systematic review and meta-analysis.

Paglioni MP, Khurram SA, Ruiz BII, Lauby-Secretan B, Normando AG, Ribeiro ACP, Brandão TB, Palmier NR, Lopes MA, da Silva Guerra EN, Meleti M, Migliorati CA, Carvalho AL, de Matos LL, Kowalski LP, Santos-Silva AR.

Oral Surg Oral Med Oral Pathol Oral Radiol. 2022 Jul 21:S2212-4403(22)01054-9.

doi: 10.1016/j.oooo.2022.07.006. 

PMID: 36153299

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Modelling stromal compartments to recapitulate the ameloblastoma tumour microenvironment.

Bakkalci D, Zubir AZA, Khurram SA, Pape J, Heikinheimo K, Fedele S, Cheema U.

Matrix Biol Plus. 2022 Nov 21;16:100125.

doi: 10.1016/j.mbplus.2022.100125. eCollection 2022 Dec.

PMID: 36452176 

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Keratoameloblastoma: A Report of Seven New Cases and Review of Literature.

Robinson L, Smit C, Fonseca FP, Abrahão AC, Romañach MJ, Khurram SA, Hunter KD, Speight PM, van Heerden WFP.

Head Neck Pathol. 2022 Jul 21. doi: 10.1007/s12105-022-01470-5. Online ahead of print.

PMID: 35861917

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Molecular profile of head and neck rhabdomyosarcomas: A systematic review and meta-analysis.

Gallagher KPD, van Heerden W, Said-Al-Naief N, Carlos R, Arboleda LPA, Rodrigues-Fernandes CI, Araújo ALD, Fonseca FP, Pontes HAR, Innocentini LMAR, Romañach MJ, Vargas PA, Lopes MA, Santos-Silva AR, Khurram SA.

Oral Surg Oral Med Oral Pathol Oral Radiol. 2022 Sep;134(3):354-366. doi: 10.1016/j.oooo.2021.12.128. Epub 2021 Dec 25.

PMID: 35840496 

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Distribution and Frequency of Salivary Gland Tumours: An International Multicenter Study.

Alsanie I, Rajab S, Cottom H, Adegun O, Agarwal R, Jay A, Graham L, James J, Barrett AW, van Heerden W, de Vito M, Canesso A, Adisa AO, Akinshipo AO, Ajayi OF, Nwoga MC, Okwuosa CU, Omitola OG, Orikpete EV, Soluk-Tekkesin M, Bello IO, Qannam A, Gonzalez W, Pérez-de-Oliveira ME, Santos-Silva AR, Vargas PA, Toh EW, Khurram SA.

Head Neck Pathol. 2022 May 27. doi: 10.1007/s12105-022-01459-0. Online ahead of print.

PMID: 35622296

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Automated Oral Epithelial Dysplasia Grading Using Neural Networks and Feature Analysis.

Azarmehr N, Shephard A, Mahmood H, Rajpoot NM, Khurram SA.

MIDL 2022.

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A Fully Automated Multi-Scale Pipeline for Oral Epithelial Dysplasia Grading and Outcome Prediction.

Shepherd A, Azarmehr N, Bashir RMS, Raza SEA, Mahmood H, Khurram SA, Rajpoot NM.

MIDL 2022.

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Prediction of malignant transformation and recurrence of oral epithelial dysplasia using architectural and cytological feature specific prognostic models.

Mahmood H, Bradburn M, Rajpoot N, Islam NM, Kujan O, Khurram SA.

Mod Pathol. 2022 Mar 31. doi: 10.1038/s41379-022-01067-x. 

PMID: 35361889

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On Smart Gaze based Annotation of Histopathology Images for Training of Deep Convolutional Neural Networks.

Mariam K, Afzal OM, Hussain W, Javed MU, Kiyani A, Rajpoot N, Khurram SA, Khan HA.

IEEE J Biomed Health Inform. 2022 Feb 7;PP. doi: 10.1109/JBHI.2022.3148944. 

PMID: 35130177

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Stain-Robust Mitotic Figure Detection for the Mitosis Domain Generalization Challenge.

Bashir RMS, Bilal M, Khurram SA, Minhas F, Rajpoot NM.

Biomedical Image Registration, Domain Generalisation and Out-of-distribution Analysis: MICCAI 2021 Challenges: MIDOG 2021, MOOD 2021, and Learn2Reg 2021: Held in Conjunction with MICCAI 20201, Strasbourg, France, September 27-October 1, 2021: Proceedings.

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The need for communication between clinicians and pathologists in the context of oral and maxillofacial diseases.

Pérez-DE-Oliveira ME, Heerden WV, Motta ACF, Rodrigues-Fernandes CI, Romañach MJ, Agostini M, Gueiros LAM, Vargas PA, Lopes MA, Ribeiro ACP, Brandão TB, Almeida OP, Khurram SA, Santos-Silva AR.

Braz Oral Res. 2022 Jan 14;36:e008. doi: 10.1590/1807-3107bor-2022.vol36.0008. eCollection 2022.

PMID: 35081226

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A digital score of tumour-associated stroma infiltrating lymphocytes predicts survival in head and neck squamous cell carcinoma.

Shaban M, Ahmed Raza SE, Hassan M, Jamshed A, Mushtaq S, Loya A, Batis N, Brooks J, Nankivell P, Sharma N, Robinson M, Mehanna H, Khurram SA, Rajpoot N.

J Pathol. 2021 Oct 26. doi: 10.1002/path.5819. Online ahead of print.

PMID: 34698394

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Cytochrome P450 isoforms 1A1, 1B1 AND 2W1 as targets for therapeutic intervention in head and neck cancer.

Presa D, Khurram SA, Zubir AZA, Smarakan S, Cooper PA, Morais GR, Sadiq M, Sutherland M, Loadman PM, McCaul J, Shnyder SD, Patterson LH, Pors K.

Sci Rep. 2021 Sep 23;11(1):18930. doi: 10.1038/s41598-021-98217-z.

PMID: 34556703

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Malignant transformation in a cohort of patients with oral epithelial dysplasia.

Hankinson PM, Mohammed-Ali RI, Smith AT, Khurram SA.

Br J Oral Maxillofac Surg. 2021 Mar 3:S0266-4356(21)00085-1. doi: 10.1016/j.bjoms.2021.02.019. PMID: 34303542

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Pakistan Oral Cancer Collaborative: analyzing barriers and obstacles to oral cancer diagnosis, treatment, and prevention in Pakistan.

Khokhar MA, Niaz MO, Aslam A, Khan HA, Loya A, Speight PM, Khurram SA.

Oral Surg Oral Med Oral Pathol Oral Radiol. 2021 Sep;132(3):312-319. doi: 10.1016/j.oooo.2021.04.058. PMID: 34284963

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Burkitt lymphoma of the head and neck: An international collaborative study.

Arboleda LPA, Rodrigues-Fernandes CI, Mariz BALA, de Andrade BAB, Abrahão AC, Agostini M, Romañach MJ, Pontes HAR, Fonseca FP, Robinson L, van Heerden WFP, Carlos R, Tager EMJR, Hoffmann IL, Cardinalli IA, de Mendonça RMH, de Vasconcelos Carvalho M, Martins-de-Barros AV, Rocha AC, Khurram SA, Speight PM, Lopes MA, Vargas PA, de Almeida OP, Santos-Silva AR.

J Oral Pathol Med. 2021 Jul;50(6):572-586. doi: 10.1111/jop.13209.

PMID: 34091974

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Impact of tumor site on the prognosis of salivary gland neoplasms: A systematic review and meta-analysis.

Dos Santos ES, Rodrigues-Fernandes CI, Speight PM, Khurram SA, Alsanie I, Costa Normando AG, Prado-Ribeiro AC, Brandão TB, Kowalski LP, Silva Guerra EN, Lopes MA, Vargas PA, Santos-Silva AR, Leme AFP.

Crit Rev Oncol Hematol. 2021 Jun;162:103352. doi: 10.1016/j.critrevonc.2021.103352.

PMID: 33991662 

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Microsecretory Adenocarcinoma of Salivary Glands: An Expanded Series of 24 Cases.

Bishop JA, Sajed DP, Weinreb I, Dickson BC, Bilodeau EA, Agaimy A, Franchi A, Khurram SA, Da Forno P, Robledo J, Kalmar JR, Aguirre S, Krane JF, Tapia JL, Kiss K, Cordell K, Rosebush M, Barrett AW, Oda D, Assaad A, Nagao T, Kawakami F, Nakaguro M, Zahir I, Wakeman K, Ihrler S, Chenevert J, Lin YL, Westra WH, Gagan J, Rooper LM.

Head Neck Pathol. 2021 May 12. doi: 10.1007/s12105-021-01331-7.

PMID: 33982215

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Artificial Intelligence-based methods in head and neck cancer diagnosis: an overview.

Mahmood H, Shaban M, Rajpoot N, Khurram SA.

Br J Cancer. 2021 Jun;124(12):1934-1940. doi: 10.1038/s41416-021-01386-x. Epub 2021 Apr 19.

PMID: 33875821 

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Convolutional Neural Network-Based Clinical Predictors of Oral Dysplasia: Class Activation Map Analysis of Deep Learning Results.

Camalan S, Mahmood H, Binol H, Araújo ALD, Santos-Silva AR, Vargas PA, Lopes MA, Khurram SA, Gurcan MN.

Cancers (Basel). 2021 Mar 14;13(6):1291. doi: 10.3390/cancers13061291.

PMID: 33799466

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Observer agreement in the diagnosis of oral lichen planus using the proposed criteria of the American Academy of Oral and Maxillofacial Pathology.

Idrees M, Farah CS, Khurram SA, Firth N, Soluk-Tekkesin M, Kujan O.

J Oral Pathol Med. 2021 May;50(5):520-527. doi: 10.1111/jop.13170.

PMID: 33730381

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Fully digital pathology laboratory routine and remote reporting of oral and maxillofacial diagnosis during the COVID-19 pandemic: a validation study.

Araújo ALD, do Amaral-Silva GK, Pérez-de-Oliveira ME, Gallagher KPD, López de Cáceres CVB, Roza ALOC, Leite AA, Mariz BALA, Rodrigues-Fernandes CI, Fonseca FP, Lopes MA, Speight PM, Khurram SA, Júnior JJ, Martins MD, de Almeida OP, Santos-Silva AR, Vargas PA.

Virchows Arch. 2021 Mar 13:1-11. doi: 10.1007/s00428-021-03075-9. Online ahead of print.

PMID: 33713188

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Self-Path: Self-supervision for Classification of Pathology Images with Limited Annotations.

Koohbanani NA, Unnikrishnan B, Khurram SA, Krishnaswamy P, Rajpoot N.

IEEE Trans Med Imaging. 2021 Feb 1;PP. doi: 10.1109/TMI.2021.3056023. Online ahead of print.

PMID: 3352380

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Multibeat Echocardiographic Phase Detection Using Deep Neural Networks.

Lane ES, Azarmehr N, Jevsikov J, Howard JP, Shun-shin MJ, Francis DP, Zolgharni M.

Computers in Biology and Medicine. https://doi.org/10.1016/j.compbiomed.2021.104373

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An optimisation-based iterative approach for speckle tracking echocardiography.

Azarmehr N, Ye X, Howes JD, Docking B, Howard JP, Francis DP, Zolgharni M.

Med Biol Eng Comput. 2020 Jun;58(6):1309-1323. doi: 10.1007/s11517-020-02142-8. Epub 2020 Apr 7.

PMID: 32253607

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NUT Carcinoma Arising from the Parotid Gland: A Case Report and Review of the Literature.

Saik WN, Da Forno P, Thway K, Khurram SA.

Head Neck Pathol. 2020 Dec 22. doi: 10.1007/s12105-020-01254-9. Online ahead of print.

PMID: 33351171

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Clinicopathological analysis and survival outcomes of primary salivary gland tumors in pediatric patients: A systematic review.

Louredo BVR, Santos-Silva AR, Vargas PA, Ajudarte Lopes M, Martins MD, Guerra ENDS, Prado Ribeiro AC, Brandão TB, de Mendonça RMH, Kowalski LP, Speight PM, Khurram SA, Pérez-de-Oliveira ME.

J Oral Pathol Med. 2020 Dec 12. doi: 10.1111/jop.13151. Online ahead of print.

PMID: 3331434

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Automated feature detection in dental periapical radiographs by using deep learning.

Khan HA, Haider MA, Ansari HA, Ishaq H, Kiyani A, Sohail K, Muhammad M, Khurram SA.

Oral Surg Oral Med Oral Pathol Oral Radiol. 2020 Aug 27:S2212-4403(20)31173-1. doi: 10.1016/j.oooo.2020.08.024. Online ahead of print.

PMID: 32950425

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The use of digital microscopy as a teaching method for human pathology: a systematic review.

Rodrigues-Fernandes CI, Speight PM, Khurram SA, Araújo ALD, Perez DEDC, Fonseca FP, Lopes MA, de Almeida OP, Vargas PA, Santos-Silva AR.

Virchows Arch. 2020 Oct;477(4):475-486. doi: 10.1007/s00428-020-02908-3. Epub 2020 Aug 24.

PMID: 3283303

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Use of artificial intelligence in diagnosis of head and neck precancerous and cancerous lesions: A systematic review.

Mahmood H, Shaban M, Indave BI, Santos-Silva AR, Rajpoot N, Khurram SA.

Oral Oncol. 2020 Nov;110:104885. doi: 10.1016/j.oraloncology.2020.104885. Epub 2020 Jul 13.

PMID: 32674040

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The chemokine lymphotactin and its recombinant variants in oral cancer cell regulation.

Abdullah Zubir AZ, Whawell SA, Wong TS, Khurram SA.

Oral Dis. 2020 Nov;26(8):1668-1676. doi: 10.1111/odi.13500. Epub 2020 Jun 30.

PMID: 32562323

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An unusual cause of a common presentation: a case of metastatic basal cell carcinoma.

Hankinson P, Collins LHC, Nusrath M, Al-Omari A, Khurram SA.

Br J Oral Maxillofac Surg. 2020 Oct;58(8):1046-1048. doi: 10.1016/j.bjoms.2020.04.037. Epub 2020 May 12.

PMID: 32409129

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Oral cancer stem cells drive tumourigenesis through activation of stromal fibroblasts.

Al-Magsoosi MJN, Lambert DW, Khurram SA, Whawell SA.

Oral Dis. 2020 Jun 27. doi: 10.1111/odi.13513. Online ahead of print.

PMID: 32593227

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A Novel Digital Score for Abundance of Tumour Infiltrating Lymphocytes Predicts Disease Free Survival in Oral Squamous Cell Carcinoma.

Shaban M, Khurram SA, Fraz MM, Alsubaie N, Masood I, Mushtaq S, Hassan M, Loya A, Rajpoot NM.

Sci Rep. 2019 Sep 16;9(1):13341. doi: 10.1038/s41598-019-49710-z.

PMID: 31527658

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Beauty is only mucosa deep: a retrospective analysis of oral lumps and bumps caused by cosmetic fillers.

Martin LHC, Hankinson PM, Khurram SA.

Br Dent J. 2019 Aug;227(4):281-284. doi: 10.1038/s41415-019-0622-y.

PMID: 31444444

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Extranodal extension in oral cancer: A role for the nodal microenvironment?

Pilborough AE, Lambert DW, Khurram SA.

J Oral Pathol Med. 2019 Nov;48(10):863-870. doi: 10.1111/jop.12870. Epub 2019 May 21.

PMID: 3108739

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Methods for Segmentation and Classification of Digital Microscopy Tissue Images.

Vu QD, Graham S, Kurc T, To MNN, Shaban M, Qaiser T, Koohbanani NA, Khurram SA, Kalpathy-Cramer J, Zhao T, Gupta R, Kwak JT, Rajpoot N, Saltz J, Farahani K.

Front Bioeng Biotechnol. 2019 Apr 2;7:53. doi: 10.3389/fbioe.2019.00053. eCollection 2019.

PMID: 31001524

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Characterisation of DOG-1 Expression in Salivary Gland Tumours and Comparison with Myoepithelial Markers.

Khurram SA, Speight PM.

Head Neck Pathol. 2019 Jun;13(2):140-148. doi: 10.1007/s12105-018-0917-3. Epub 2018 Apr 18.

PMID: 29671211

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Oral potentially malignant disorders: risk of progression to malignancy.

Speight PM, Khurram SA, Kujan O.

Oral Surg Oral Med Oral Pathol Oral Radiol. 2018 Jun;125(6):612-627. doi: 10.1016/j.oooo.2017.12.011. Epub 2017 Dec 29.

PMID: 29396319

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Cancer-associated fibroblasts promote bone invasion in oral squamous cell carcinoma.

Elmusrati AA, Pilborough AE, Khurram SA, Lambert DW.

Br J Cancer. 2017 Sep 5;117(6):867-875. doi: 10.1038/bjc.2017.239. Epub 2017 Jul 25.

PMID: 28742795

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Epigenetic changes in histone acetylation underpin resistance to the topoisomerase I inhibitor irinotecan.

Meisenberg C, Ashour ME, El-Shafie L, Liao C, Hodgson A, Pilborough A, Khurram SA, Downs JA, Ward SE, El-Khamisy SF.

Nucleic Acids Res. 2017 Feb 17;45(3):1159-1176. doi: 10.1093/nar/gkw1026.

PMID: 28180300

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Cytogenetic and immunohistochemical characterization of mammary analogue secretory carcinoma of salivary glands.

Khurram SA, Sultan-Khan J, Atkey N, Speight PM.

Oral Surg Oral Med Oral Pathol Oral Radiol. 2016 Dec;122(6):731-742. doi: 10.1016/j.oooo.2016.07.008. Epub 2016 Jul 20.

PMID: 27720350

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Accuracy of staging of oral squamous cell carcinoma of the tongue: should incisional biopsy be done before or after magnetic resonance imaging?

Howe TE, Khurram SA, Hunter K, Martin LH, Fry AM.

Br J Oral Maxillofac Surg. 2017 Apr;55(3):298-299. doi: 10.1016/j.bjoms.2016.09.004. Epub 2016 Sep 24.

PMID: 27682718

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The chemokine receptors CXCR1 and CXCR2 regulate oral cancer cell behaviour.

Khurram SA, Bingle L, McCabe BM, Farthing PM, Whawell SA.

J Oral Pathol Med. 2014 Oct;43(9):667-74. doi: 10.1111/jop.12191. Epub 2014 Jun 26.

PMID: 24965032

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Functional expression of the chemokine receptor XCR1 on oral epithelial cells.

Khurram SA, Whawell SA, Bingle L, Murdoch C, McCabe BM, Farthing PM.

J Pathol. 2010 Jun;221(2):153-63. doi: 10.1002/path.2695.

PMID: 20225245

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